Principes d’application clinique de la photothérapie dynamique
Principles of clinical photodynamic therapy
The implementation of Photodynamic Therapy (PDT) requires a drug (photosensitizer), a light source and a light applicator. By light activation of the photosensitizer, reactive oxygen species are produced that induce damage to sub-cellular structures. Photosensitizers with a preferential accumulation in pathological tissue may thus be used to destroy this tissue whether visible or not. With this aim, intense but non-thermal light is homogenously irradiated onto the target tissue with appropriate light applicators for flat, cylindrical or spherical organ geometries. Recent research and development of all necessary components has brought about significant progress in efficiency, reliability and cost effectiveness.
Several photosensitizers have already obtained drug approval for certain applications, further can be anticipated for the near future. Considerable clinical experience has been reported for the treatment of Barrett’s esophagus and palliative treatment of cholangiocarcinoma is very promising.
fluorescence diagnosis, light applicators, light sources, photodynamic therapy (PDT), photosensitizer