Dysplasie (néoplasie intraépithéliale) et maladies inflammatoires chroniques idiopathiques du côlon (MICI)
Dysplasia (intraepithelial neoplasia) and chronic inflammatory bowel disease (IBD)
Although colorectal cancer complicating chronic inflammatory bowel diseases (IBD) only accounts for 1–2 % of all cases of colorectal cancer in the general population, it is considered to be a serious risk. The development of cancer in IBD is often associated with the appearance of precancerous lesions, known as dysplasia. These lesions constitute a good diagnostic marker. Dysplastic lesions in IBD are characterized by specific macroscopic appearances, described as DALM (dysplasia associated lesion or mass). In the present review the different macroscopic types of dysplasia are described and the diagnostic features and classification are reviewed. Furthermore, the impact of molecular techniques and the influence of the better understanding of the genetic abnormalities for the diagnosis are discussed.
Anne JOURET, K. GEBOES
adenoma, DALM, dysplasia, IBD, molecular pathways